A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus
نویسندگان
چکیده
منابع مشابه
Sumoylation Silences the Plasma Membrane Leak K+ Channel K2P1
Reversible, covalent modification with small ubiquitin-related modifier proteins (SUMOs) is known to mediate nuclear import/export and activity of transcription factors. Here, the SUMO pathway is shown to operate at the plasma membrane to control ion channel function. SUMO-conjugating enzyme is seen to be resident in plasma membrane, to assemble with K2P1, and to modify K2P1 lysine 274. K2P1 ha...
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Background and Objective: In temporal lobe epilepsy (TLE), recurrent seizures accompany with cognitive deficit. In some patients, the current medications cannot provide satisfactory control of seizures, therefore new drugs that act through different mechanisms are required. In the present study, the useful effect of dipeptidyl peptidase-4 inhibitor was evaluated in experimental model of tempora...
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Status epilepticus (SE) describes persistent or recurring seizures without a return to baseline mental status and is a common neurologic emergency. SE can occur in the context of epilepsy or may be symptomatic of a wide range of underlying etiologies. The clinician's aim is to rapidly institute care that simultaneously stabilizes the patient medically, identifies and manages any precipitant con...
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Epilepsy is associated with loss of expression and function of hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channels. Previously, we showed that loss of HCN channel-mediated current (I(h)) occurred in the dendrites of CA1 hippocampal pyramidal neurons after pilocarpine-induced status epilepticus (SE), accompanied by loss of HCN1 channel protein expression. However, the precise...
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objective status epilepticus (se) has been described as a series of major motor seizure without recovery of consciousness between seizures. se is a medical emergency that requires prompt diagnosis and appropriate treatment. in this article we shall conclude history, epidemiology, etiology, risk factors, the best management as well as the prognosis of the condition.
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2013
ISSN: 0013-9580
DOI: 10.1111/epi.12472